J. Philipp Centers for Family and Cosmetic Dentistry, 3230 S Gilbert Rd #4, Chandler, Az 85286
Retentivity of Neutralizing response against SARS-CoV-ii Omicron variant in Sputnik Five vaccinated individuals
Abstract
The new variant Omicron (B.1.1.529) of SARS-CoV-ii, outset identified in November 2021, is rapidly spreading all around the world. The Omicron becomes the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on neutralizing activity of vaccinated sera against Omicron variant are currently being carried out in many laboratories.
In this study, we have shown the neutralizing action of sera against SARS-CoV-2 Omicron (B.one.1.529) variant compared to the reference Wuhan D614G (B.1) variant in individuals vaccinated with 2 doses of Sputnik V or BNT162b2 in different time points up to vi months afterward vaccination. Nosotros performed analysis on sample pools with comparable NtAb to Wuhan D614G variant. The decrease in neutralizing antibiotic (NtAb) to the Omicron variant was eight.1 folds for group of Sputnik V-vaccinated and 21.4 folds for group of BNT162b2-vaccinated. Analysis showed that 74.ii% of Sputnik V- and 56.9% of BNT162b2-vaccinated sera had detectable NtAb to SARS-CoV-2 Omicron variant.
The subtract in NtAb to SARS-CoV-2 Omicron variant compared to Wuhan variant has been shown for many COVID-19 vaccines in apply, with some showing no neutralization at all. Today the necessity of third booster vaccination is obvious. And the most effective arroyo, already shown in several studies, is the use of heterologous booster vaccination pioneered in COVID-19 vaccines by Sputnik V.
Competing Interest Statement
GDM, DIV, SDV, TAI, ZOV, LDY, NBS and GAL written report patents for a Sputnik V immunobiological expression vector, pharmaceutical agent, and its method of utilise to prevent COVID-19. LD, MG, MS, CF, BA, GG, FM, GAR, PV, VF, declare no conflict of interest. AA declares no conflict of interest for the present work, and, outside of the nowadays work, declares honoraria for consultancy, lectures or research grants from Gilead, Merck, Astra Zeneca, Roche, ViiV, GSK, Janssen, Mylan, Theratecnologies. EG declares no disharmonize of interest for the present work, and, outside of the present piece of work, declares honoraria for consultancy, lectures or inquiry grants from Gilead, ViiV, Mylan.
Funding Statement
This report was funded by Russian Straight Investment Fund.
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I confirm all relevant upstanding guidelines have been followed, and whatsoever necessary IRB and/or ethics committee approvals have been obtained.
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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The written report was conducted according to the guidelines of the Declaration of Helsinki, and approved past the INMI Ethical Commission (issue n. 297/2021) and Gamaleya NRCEM Local Ethics Commission (Protocol No. 17 of December 03, 2021).
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Data Availability
All data produced in the present piece of work are independent in the manuscript
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The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to brandish the preprint in perpetuity. All rights reserved. No reuse immune without permission.
Source: https://www.medrxiv.org/content/10.1101/2022.01.15.22269335v1
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